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KMID : 1161520020060010081
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Animal Cells and Systems
2002 Volume.6 No. 1 p.81 ~ p.84
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Isolation and phytogeny of SINE-R retroposons derived from human endogenous retrovirus HERV-K family in schizophrenia
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Kim Heui-Soo
Crow Timothy J.
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Abstract
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SINE?R retroposons have been derived from human endogenous retrovirus HERV?K family and found to be hominoid specific. Both SINE?R retroposons and HERV?K family are potentially capable of affecting the expression of closely located genes. Using the genomic DNA from patients with schizophrenia, we identified 26 SINE?R retroposons and analyzed them with the sequences derived from the hominoid primates. The SINE?R retroposons from schizophrenia showed 89.7?96.6% sequence similarities with the sequence of the schizo?cDNA clone that derived from postmortem tissue from the frontal cortex of an individual suffering from schizophrenia. Phylo?genetic analysis using the neighbor?joining method revealed that the new SINE?R retroposons in schizophrenia have proliferated independently during hominid evolution. Such retroposons have great relevance to genomic change connected to human diseases. The data suggest that new SINE?R retroposons identified in schizophrenia deserve further investigation as potential leads on the understanding of neuropsychiatric diseases.
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KEYWORD
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HERV-K family, Phylogeny, Schizophrenia, SINE-R retroposon
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